semaglutide percent weight loss Depicts the mean percentage of over time by medication U.S. FDA | The FDA

When to talk to a doctor Eapen, MD advises, Talk to your doctor if you cannot get relief from constipation from these methods, if constipation lasts over two weeks, you feel pain, or if you see blood in your stool. Your doctor may ask you to take over-the-counter fiber supplements, magnesium, or even stool softeners and laxatives like MiraLAX to gain some short-term relief. If these methods don't provide relief from your constipation, your doctor may consider adjusting your semaglutide dose

Nausea remains the most common side effect, even with the B12 addition

Most patients describe it as manageable

Its rare but can be serious

Their biggest similarities: They both affect appetite and fullness