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The drugs skyrocketed in mainstream popularity after the Food and Drug Administration began approving GLP-1 medications for weight loss over the last five years, in addition to their pre-existing approvals to treat diabetes

It should be noted that patients who have previously responded to and tolerated antidepressants are rarely included in RCTs (where prior or current antidepressant use is usually an exclusion criterion), influencing the generalisability of results from placebo-controlled trials

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