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A specific protocol was established to isolate hpCAFs from small-size specimens obtained from eco-endoscopy samples derived from PDAC patients with (dysmetabolic, D) or without (non-dysmetabolic, ND) a history of diabetes and obesity (assumed as dysmetabolic condition)

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Physical modulation of mesenchymal stem cell exosomes: a new perspective for regenerative medicine

In support of this, exploratory analyses revealed that the semaglutide group exhibited markers of more advanced metabolic disease relative to the off-semaglutide group, including a greater number of diabetes medication classes, a higher prevalence of diabetes-relevant cardiometabolic comorbidities, and a greater cardiovascular medication burden