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Another principal function of the NADPH produced by ER-localized hexose-6-phosphate dehydrogenase is to provide the reducing energy to ER-localized reductases, specifically those involved in steroid hormone metabolism, with 11-hydroxysteroid dehydrogenase 1 (11-HSD1

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found that GLP-1RAs did not significantly reduce asthma exacerbations, whereas, SGLT-2 inhibitors (SGLT-2i) were associated with a reduced risk of asthma compared to both GLP-1RAs and DPP-4 inhibitors (DPP-4i) [101]