Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
Gut Variations This may be more effective when comparing B12 tablets vs sprays, because the environment of the gut differs from person to person
The body stores some B12 in the liver, but excess amounts are flushed out of the body through urine
Reduced appetite means smaller portions, and reduced volume means every bite needs to count nutritionally
Many clinics offer MIC (methionine, inositol, choline) blends with B-vitamins , sometimes with L-carnitine , as part of structured weight-management programs