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However, despite their health benefits, the low absorption rate of polyphenols (approximately 510% via the small intestine) and their rapid metabolism and excretion significantly limit their ability to reach target tissues (114)

While it didn't prove effective for that specific purpose, researchers discovered its remarkable ability to stimulate growth hormone release with exceptional selectivityleading to its current use in performance, anti-aging, and wellness applications

Nrf2 depletion in macrophages leads to increased foam cell formation, increases the M1 inflammatory phenotype with enhanced expression of pro-inflammatory monocyte chemoattractant protein-1 and interleukin-6, and aggravates atherosclerosis (244, 245)

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