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122,123,124 Gln enters the cell via the amino acid transporter ASCT2/SLC1A5 and is converted to glutamate in the mitochondria by a deamination reaction involving glutaminase (GLS)

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On the other hand, erastin-induced ferroptosis is suppressed by downregulating Atg5 and Atg7 through reducing intracellular ferrous iron levels and lipid peroxidation ( 4 Treatment DKD is a chronic complication of diabetes, improvements in glycemia control and blood pressure management by blocking the RAAS, currently available therapies could not be able to prevent progression to ESRD completely

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