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Natural Medicine Journal Research Guide

NAD+ works as a redox coenzyme by accepting hydride ions (a proton with two electrons) from metabolic processes including: Glycolysis The tricarboxylic acid (TCA) cycle Fatty acid oxidation During these reactions, NAD+ changes to NADH, which then gives electrons to the electron transport chain to make ATP

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In this study, we hypothesized that FOXO4-DRI treatment could remove the senescent cells in the expanded chondrocytes, thus enhancing their potential in generating high-quality cartilage