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Modified-release pulmonary delivery systems for labile bioactives: Design, development, and applications

The compound's reputation rests on preclinical animal and in-vitro work, much of which is now compromised

Formalin-fixed, paraffin-embedded serial tissue sections (5 m of thickness) from control or ALCAR treated tumours (DU-145 and 22Rv1) were deparaffinised with xylene and rehydrated in graded ethanol, followed by haematoxylin and eosin staining

GSH inhibitors such as buthionine sulfoximine (BSO) were found to improve chemosensitivity in cancer cells

Most research indicates that standard creatine supplementation provides consistent benefits across the menstrual cycle, with no evidence suggesting that varying intake timing or dosage significantly enhances the effects in relation to hormonal fluctuations