Patients who commit to a multi-cycle series report a compounding improvement pattern: the first cycle establishes the biological foundation, and subsequent cycles build on it, consistent with what we see across all peptide protocols at Perfect B
Its significant influence on reticulin and collagen formation, angiogenesis, and immune system components positions it as a potential therapeutic tool for wound healing management
Keep the vial in its original box or a dark container to protect it from light, as prolonged light exposure can also contribute to degradation
The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months
Side effects Semaglutide also induces gastrointestinal disturbance, although pooled analysis of SUSTAIN 1-5 found comparable safety profiles in older and younger adults [98]