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Based on the THCA prognostic risk model, we screened the key molecule Ribonucleotide reductase M2 ( RRM2 ) subunit, which has a potential pro-cancer role, to explore the functional role of RRM2 and its molecular mechanism in PTC, and to investigate the effects of RRM2 on the proliferation, apoptosis, migration invasion, cell cycle, and tumorigenicity of PTC cells in vivo

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Combination regimens with CQ/HCQ improve outcomes when paired with radiation therapy in brain metastases, 284,285 HDAC inhibitors such as vorinostat, 286 mTOR inhibitors such as temsirolimus, 287 temozolomide, 288 proteasome inhibitors such as bortezomib, 289 gemcitabine in pancreatic ductal adenocarcinoma, 290 and erlotinib in non-small cell lung cancer (Fig