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The mechanism-based rationale for concerns is strong, however, especially if applied to settings in which these peptides are used on a long-term basis [2, 24]

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Conclusion: Semaglutide and tirzepatide may share common targets ( Cyp1a1 , Hsd11b1 , and Atp1a3 ) that enhance insulin sensitivity, improve metabolism, and promote weight loss

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These findings are important because they demonstrate that androgen excess begins early in life in the context of obesity, establishing a potential mechanistic link to later reproductive and metabolic disorders such as polycystic ovary syndrome