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Novo Nordisk makes a GLP-1 drug called semaglutide, which it sells as Wegovy for weight loss and Ozempic for type 2 diabetes

All animal experiments were performed with the approval of the Institutional Animal Care and Use Committees at the University of Utah

Other activators of pancreatic beta cells Incretin hormone receptor agonists (discussed below) can reduce beta cell apoptosis in vitro and in animal models, probably via cAMP and protein kinase A (PKA) activation, and provide the best evidence-supported opportunity to preserve the beta cell population at this time

Wnt/-catenin pathway in bone disease Osteocytes play a central role in regulating bone metabolism and can regulate the balance of bone formation and bone resorption in bone modelling and remodelling through endocrine and autocrine methods