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TB-500 has been shown to promote cell migration, angiogenesis, cytoskeletal reorganization, and anti-inflammatory signaling in preclinical models 1,2

1C, left panel)

HSA acts as an endogenous inhibitor of A and prevents A deposition associated with AD [70]

Animal studies show substantial evidence across stroke models (full functional recovery in spatial memory, motor coordination, balance), Parkinsons models (protection of dopaminergic neurons, near-complete prevention of mortality), multiple sclerosis models (significantly less brain damage), and traumatic brain injury (reduced hemorrhage and edema)

The combination of high initial levels after injection and brain exposure is considered the likely cause of side effects such as nausea and vomiting