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A 2020 study found that the death rate among people with the highest levels of B12 in their bodies was almost twice as high as that of people with the lowest levels of B12

While no clinical trials have firmly established its efficacy or safety in humans, the volume of in-vitro and animal model data provides a compelling rationale for its continued investigation

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They must either have: BMI of at least 35 BMI of at least 30 plus a history of heart failure, uncontrolled hypertension or chronic kidney disease BMI of at least 27 plus prediabetes, a previous heart attack or stroke, or symptomatic peripheral artery disease

No significant change was observed for those on weekly GLP-1 RAs