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However, the specific interactions depend on concentration and formulation details

Nitrate supplementation resulted in reduced oxygen uptake (VO 2 ) at moderate and severe intensities and a reduced VO 2 at the time of exhaustion (Lansley et al., 2011b)

doi:10.1002/pros.22999

However, off-label use does not change the FDA approval status, does not obligate an insurance plan to cover the prescription, and does not mean the agency reviewed evidence for that purpose