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Pathophysiologically, MASLD is strongly associated with insulin resistance, leading to hepatic lipid accumulation, inflammation, and in advanced stages, fibrosis and cirrhosis

A minimum weight gain, and no weight loss, is currently recommended for all pregnant women, including those who are already overweight or obese, due to the obligatory weight gain that occurs in maternal tissues during pregnancy with chronic malabsorption syndrome with cholestasis with known hypersensitivity to Orlistat or to any component of this product Warnings and Precautions: Orlistat may interact with concomitant drugs including cyclosporine, levothyroxine, warfarin, amiodarone, antiepileptic drugs, and antiretroviral drugs Orlistat can decrease cyclosporine exposure

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Exp Brain Res 118 : 5260