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Because sitagliptin is substantially excreted by the kidney, and because aging can be associated with reduced renal function, renal function should be assessed more frequently in elderly patients [see Dosage and Administration (2.2), Warnings and Precautions (5.3)] Sitagliptin is excreted by the kidney, and sitagliptin exposure is increased in patients with renal impairment

These hormonal shifts can be the result of conditions like menopause, mood disorders, or obesity

Circulating systemic serum glutathione appeared to be decreased in the old group compared to the young group, but the difference was not significance ( p -value: 0.1143)

The global burden of Sepsis and septic shock

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