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Severe symptoms are those that interfere with your quality of life

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Despite the widespread use of levothyroxine replacement therapy, a substantial proportion of patients continue to experience persistent symptoms and metabolic dysregulation even after achieving biochemical euthyroidism

To also test the maximal possible increase in efficacy of the two drugs when given together, we administered single injections of 4 ml with increasing doses of L838,417 and a constant dose of CLP257 (100 mg kg 1 )