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6) Vogt, Barbara L., and John P

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De novo lipogenesis regulation in adipose is similar to that in livers, wherein adipose-ChREBP is a major determinant of adipose tissue fatty acid production and systemic insulin sensitivity, that is induced by GLUT4-mediated glucose uptake, and genetically ablating ChREBP impairs insulin sensitivity in adipose tissue 123 In addition, lipogenic gene FASN and DGAT mRNA expression in adipose tissue have been shown to correlate strongly and positively with insulin sensitivity, which were may reduced by larger adipocytes in adipose tissue of obese individuals

These genetic insights reveal how your body processes GLP-1 compounds at the molecular level, helping your healthcare provider anticipate whether you may need dosing adjustments or whether you might benefit from combination therapy