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Whether the GLP-1 is making an animal feel full faster and then those signals are whats turning down dopamine or if GLP-1 is acting directly on the dopamine receptors, so that theyre less responsive, I dont know the answer to that, said Daniels

However, the effects of acute peripheral liraglutide are preserved in 5-HT 2C receptor KO mice [111], again suggesting different central pathways are targeted by endogenous GLP-1 and GLP-1R agonists

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Gastrointestinal side effects such as nausea, vomiting, and diarrhea are common with tirzepatide, particularly during dose escalation

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