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The inclusion of participants from 40 countries and 566 centers should facilitate the enrollment of an ethnically diverse population, improving the representativeness of the trial population

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Comparative safety data shows acute kidney injury was listed in 0.47% of tirzepatide adverse event reports versus 1.07% of semaglutide reports in the FDA Adverse Event Reporting System (FAERS), with the reporting odds ratio favoring tirzepatide