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tirzepatide is a dual agonist (GIP/GLP-1) Peak weight loss : Retatrutide showed 28.7% at 68 weeks (Phase 3 TRIUMPH-4) and 24.2% at 48 weeks (Phase 2) vs tirzepatide 20.9% (Phase 3) Liver fat : Retatrutide's glucagon agonism provides pronounced hepatic fat reduction (up to 82%) Regulatory status : Tirzepatide is FDA-approved

GH-mediated lipolysis increases free fatty acid availability

These findings delineate Drp1s dual regulatory role in mitochondrial dynamics and quality control, providing novel therapeutic avenues for ALS targeting mitochondrial proteostasis

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