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Here we summarized the current experience of the research groups worldwide in modeling of GC undesirable effects and presented the most valid animal models for studying the effects of both GC and their analogues on bone tissue, muscles, skin, as well as carbohydrate and fat metabolism

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However, McCombe and Henderson [23] noted that It is possible that individual variability in immune responsiveness means that individual patients have different immune responses in ALS. A clear understanding of the dynamic changes that occur within the immune system over the course of disease [104] is essential for developing an effective treatment for ALS

This idea is rooted in chrono-urbanism, which argues that the quality of urban life declines as the time and financial resources devoted to transportation increase (Moreno et al., 2016