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From baseline until 1 week after the last dose of randomised treatment, a total of 13 participants (3.8%) in the IcoSema group and 71 participants (20.8%) in the semaglutide group initiated non-randomised insulin or additional non-insulin glucose-lowering medications for more than 2 weeks, with most of them initiating oral glucose-lowering medications rather than insulin treatment

NAD+ Nicotinamide adenine dinucleotide, or NAD+, is a coenzyme involved in hundreds of cellular reactions

It functions as a GLP-1 receptor agonist, targeting brain areas responsible for appetite control , thereby helping to decrease hunger and reduce calorie intake

Calcium Pyruvate (Medical grade) Calcium pyruvate is a naturally occurring compound that combines calcium with pyruvic acid

For weight management, NICE provides guidance on eligibility for specialist weight management services, which may include other pharmacological options such as orlistat (though this can also cause gastrointestinal side effects that may be problematic in IBD)