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(2014) reported a generally lower level of metabolites in PD as compared to controls, with a specific decrease in 3-hydroxyisovaleric acid, tryptophan, and creatinine, a significant decrease in the levels of A-38 and A-42, and an increase in soluble amyloid peptide precursor (APP) in CSF of patients

This is particularly important for individuals using GLP-1 agonists, as these medications are designed to optimize blood sugar control

This is actually reflected in dosing regimens

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