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Cost considerations for researchers Cost is a practical factor that influences which compound researchers choose

Zille et al., 2017)

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Risks include hypoglycemia, insulin resistance, fluid retention, and potential mitogenic effects , especially with long-term use

Concurrently, lack of Nrf2 decreased protein aggregation and cardiac hypertrophy and improved cardiac contractility in the mice transgenic for the mutant human B-crystallin, suggesting that the sustained upregulation of Nrf2 and subsequent increase in GSH-mediated removal of hydrogen peroxide contributes to the reductive stress phenotype [51]