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SELECT CVOT trial investigated the cardiovascular safety of semaglutide 2.4 mg therapy once a week in a group of 17,605 overweight or obese adults over the age of 45 with no history of T2DM

Because weight reduction after bariatric surgery usually peaks after 24 months, the possible effect of LIRA in poor responders after laparoscopic sleeve gastrectomy may not have been obvious during this short period of administration [116]