is metformin a glp 1 Type 2 Diabetes Medications: Metformin, GLP-1, SGLT2 & More Metformin Modulates GLP-1- and GIP-Mediated

Hong, Y., Downey, T., Eu, K

GLP-1 and GLP-1+GIP medications have substantial clinical evidence demonstrating weight reduction in studied populations when combined with lifestyle modifications

294 For example, several studies have shown that obese adults harbor reduced gut microbial diversity and altered microbiota compositions compared with adults exhibiting normal weight

In view of robust patient blood management practices and despite stringent selection criteria, only ~ 56% of enrolled subjects were transfused (site range 1882%)

Although some studies have demonstrated benefits such as increased lean body mass and improved body composition (in populations with clinical need for the drugs), these gains have not consistently translated into enhancements in muscle strength, physical performance, or overall quality of life