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Variant carriers may experience faster metabolic benefits or require different dose progressions, but individual variation is high and clinical assessment remains essential

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Furthermore, recent studies have shown that the PKD of JAK2, unlike the other members of the JAK family, exhibits some catalytic activity via autophosphorylation of two critical residues in the JH2SH2 linker region, Ser 523 and Tyr 570 , which play an important role in regulating the activity of the KD (82, 83)

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