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Ethical principles of the study ensured compliance with European Directive 010/63/E, the Law on Amendments to the Animal Protection Act (Official Gazette 37/13, the Animal Protection Act (official Gazette 135/06), Ordinance on the protection of animals used for scientific purposes (Official Gazette 55/13), FELASA recommendations, and recommendations of the Ethics Committee, School of Medicine, University of Zagreb

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After that, the scale usually plateaus