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A study in adults aged 70 and older showed increased heteroplasmy linked to an increased depression score.[ref] Rare mitochondrial mutations that cause mitochondrial diseases are also linked to major depressive disorder.[ref] In fact, one study of people with hereditary (genetic) mitochondrial diseases showed that 54% had major depressive disorder and 17% had bipolar disorder.[ref] Outside of the mitochondrial genome, genes in the nuclear genome that code for proteins in the mitochondria are also linked to depression

Due to its critical role in these cellular processes, declining levels of NAD + are associated with general aging and chronic disorders, including cognitive decline, sarcopenia, and metabolic diseases

World J Microb Biot 19(8):811815

[3] Soerjomataram I, Bray F

Research indicates that BPC-157 facilitates nerve regeneration, improves mobility, and fosters neuroprotective effects in SCI models