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It is noteworthy that iron metabolism, serving as a bridge linking the microbiota to host pathological processes, exhibits bidirectional regulatory properties: the hosts iron reserve status can significantly influence gut microbiota composition, while specific bacterial strains can reshape host iron distribution by modulating the expression of iron absorption-related proteins

By maintaining integrity of the intestinal barrier via complex mechanisms, the vagus nerve and its major neurotransmitter, acetylcholine (ACh), play a crucial role in coordinating adaptive neural and endocrine responses of the gastrointestinal system, including those against infection and inflammation (207)

Metformin, the only biguanide medication currently available for the treatment of diabetes, is considered the first-line drug for type 2 diabetes (Misbin 2004

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Hasanuzzaman, M