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Ensure that the unused medicine is disposed of properly

DOI: Published online: February 14, 2024 1 Borthwick Diabetes Research Centre, Lister Hospital, Stevenage, UK 2 Diabetes Complications Research Centre, University College Dublin, Dublin, Ireland Corresponding author: Adie Viljoen

c-KIT-mediated ERK signaling pathway can induces CREB phosphorylation to activate melanin synthesis on one hand, and on the other hand, the activation of ERK signaling has been demonstrated to phosphorylate MITF at the serine 73 residue, which leads to the ubiquitination and degradation of MITF, this is the feedback mechanism of the ERK pathway to regulate melanin production (3,35)

Immediate post-injection care focuses on minimising local reactions: Apply a cold compress to the injection site for 1015 minutes to reduce pain and swelling Avoid massaging or rubbing the area, which can increase bruising Wear loose clothing that doesn't irritate the injection site Gentle movement of the affected limb may help reduce stiffness Hydration and nutrition support general wellbeing during treatment

doi: 10.2141/jpsa.0170083