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doi:10.1016/j.tox.2011.03.001, PMID: 21414382 Valko M, Morris H, Cronin MT (2005) Metals, toxicity and oxidative stress

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Sirtuins also perform other post-translational reactions such as NAD + -dependent desuccinylation, diacylation, and demalonylation, and are important in regulating metabolism, allowing metabolic plasticity 7

Mutations were introduced in the genes encoding RAGA (Q66L) and RAGC (S75N) to lock the active state of RAG GTPases (RAGA GTP RAGC GDP )