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Studies show that single-molecule dual GIPR/GLP-1R agonists have better insulinotropic and antihyperglycemic effects than GLP-1 agonists in rodents, primates, and humans, without causing gastrointestinal disturbances [58]

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Polack G, McCray V, Tyner T, Kane S, Vu K, Yamaguchi K Jr, Merriman J, Ishimoto M, Hasson A, Sian K, Yamaguchi KT

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