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Weight reduction triggers adaptive changes in hunger and satiety hormones and energy expenditure, which favor weight regain, Neff says

These improvements may prove critical for women with PCOS should GLP-1 medications obtain the appropriate authorisation, as managing weight and insulin resistance can significantly improve overall health and fertility

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GLP-1, secreted by intestinal L cells, can participate in the regulation of a variety of CNS functions including BBB integrity (152)

A change in GSH levels is important when assessing toxicological responses and an indicator of oxidative stress, potentially leading to apoptosis or cell death