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In one study of exenatide 23 , patients underwent two phases of treatment52 weeks followed by 104 weekswith a 12-week off-treatment period after each phase

When fasting, Sirt5 knockout mouse has reduced ECHA (an enzyme regulates the oxidation of fatty acid) activity, increased long-chain acyl-CoAs content and decreased ATP content

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Alosetron (Lotronex), an antagonist of the 5-HT3 serotonin receptor, is used in females to treat severe IBS-D that is unresponsive to other treatments

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