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2024, ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/

Key finding: AOD 9604 showed superior lipolytic activity (EC50 45 nM) versus native GH (EC50 380 nM) with insulin-independent mechanism

[2] However, elevated MMA is not conclusive, as it is seen in people with B 12 deficiency, but also in elderly people who have renal insufficiency, [28] and elevated homocysteine is not conclusive, as it is also seen in people with folate deficiency

This pathway allowed AOD-9604 to be marketed in the United States as a dietary supplement without the efficacy evidence required for a New Drug Application (NDA)

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