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In addition to the generalized proximal tubule reabsorption impairment, type 2 RTA is often associated with neurological and ocular anomalies, dependent upon the gene defect

Synergistic combined effect of drugs induces cell cycle arrest, apoptosis, and alteration to mitochondrial membrane potential in cancer cells as well as down regulates the expression of CD44 receptor, which are main factor for cancer metastasis

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