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On day 0 (D0), the two groups of 7 animals were anesthetized with inhaled isoflurane/oxygen and infected intranasally with 10 5,5 TCID50 of a SARS-CoV-2 Delta (B.1.617.2) strain in 60 L of PBS

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Despite these findings involving JNK in APAP hepatotoxicity, a recent report in mice with hepatocyte-specific Jnk1 and Jnk2 deletion (Jnk hepa ) questioned the role of JNK in APAP-induced hepatotoxicity (Cubero et al., 2016)