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PMID: 22968062

Treatment for B12 deficiency without neurological involvement: For patients with haematological manifestations only (macrocytic anaemia) or asymptomatic deficiency, the regimen is hydroxocobalamin 1mg intramuscularly three times weekly for two weeks (total of six injections), followed by maintenance of 1mg every three months for life

Consider earlier administration (3+ hours before bed) to allow cortisol-modulating effects to establish before sleep pressure builds

Dosage should be tailored to body weight to achieve optimal results

Reconstitution: Add 3.0 mL bacteriostatic water ~26.7 mg/mL total concentration Component ratio: Equal low-dose peptides + higher GHK-Cu concentration Typical daily dose: ~2.67 mg once daily Measurement: 1 unit (0.01 mL) 267 mcg total peptide Administration: Once daily (subcutaneous) Storage: Refrigerate after mixing