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Its development has proceeded through phase 1, phase 2, and phase 3 trials, most prominently as the fixed-dose CagriSema combination with semaglutide, which has generated late-stage efficacy data but remains under regulatory evaluation rather than in approved clinical use

doi: 10.1038/nature00779 114 LiuXNovosedlikNWangAHudsonMLCohenILChudleyAEet al

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Many patients see initial weight reduction with consistent diet and exercise, but the effects can wane with time

42 Action on the limbic system (including the amygdala) may be of significance when considering modulation of hedonic pathways by PYY 3-36