doi: 10.1007/s00401-003-0688-z 261
[DOI] [PMC free article] [PubMed] [Google Scholar] Gachon CM, Langlois-Meurinne M, Saindrenan P
Approved in 1964 for the management of hypertension, propranolol is now used for a wide range of cardiovascular diseases, including ischemic heart disease, angina pectoris, arrhythmias, and myocardial infarction, as well as non cardiovascular conditions, including migraine, tremors and anxiety
Re-examination of the experiment by the same laboratory indicated that overproduction in MIN6 and rat islets of GDH indeed promoted conversion of glutamate to -ketoglutarate, thereby increasing TCA cycle activity without increasing the level of glutamate [74]
Efficacy results based on a preplanned PFS interim analysis, are shown in Table 12 and Figure 1