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Additionally, homotaurine reduced the increase in oxidative stress biomarkers and inflammatory cytokines, such as IL-1, IL-6, and TNF- levels, caused by VPA in rats, decreased pyknosis in the prefrontal cortex, and restored the size and number of Purkinje cells in the cerebellum and regulated the dysregulated expression of GAD67 due to VPA exposure (158)

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Jungas T, Motta I, Duffieux F, Fanen P, Stoven V, Ojcius DM

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