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Taking medications for such long periods of time may expose you to severe side effects, including the increased risk of heart attack, stomach ulcer, kidney dysfunction, mood changes, and addiction

In the hinge-latch hypothesis, the conformation of the Nrf2Keap1 complex is altered upon oxidative stress, implying that induction of target genes is only facilitated by newly synthesized Nrf2

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Materials and Methods Animals All experimental protocols in this study were approved by the Institutional Animal Care and Use Committee (nn) of Loma Linda University, were in accordance with the ARRIVE (Animal Research: Reporting in vivo Experiments) guidelines, and comply with the National Institutes of Health guidelines for the Use of Animals in Neuroscience Research