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The HCA 2 receptor activates an associated G i -type G-protein which inhibits the production of cAMP, thereby reducing the PKA-mediated phosphorylation and activation of hormone-sensitive lipase, HSL

AKR-001, an Fc-FGF21 analog, showed sustained pharmacodynamic effects on insulin sensitivity and lipid metabolism in type 2 diabetes patients

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Furthermore, the basal mean insulin was significantly higher in TT homozygotes (30.5 21.6 UI/mL) than in individuals with CC (18.5 9.8 UI/mL) or CT (19.0 10.2 UI/mL)