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A 2023 observational analysis published in the Annals of the Rheumatic Diseases found that patients with inflammatory arthritis who used GLP-1 receptor agonists had lower rates of cardiovascular events, which is notable because cardiovascular disease is a leading cause of death in RA patients

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It has also been posited to have a potential impact on the concentrations of dopamine, norepinephrine, serotonin (also known as 5-hydroxytryptamine or 5-HT), dihydroxyphenylacetic acid, and 5-hydroxyindoleacetic acid within hypothalamic cells (specifically Hypo-E22 cells)

Five duplicate wells and blank controls were used in the experiment