In contrast, probiotic intervention antagonizes ferroptosis through mechanisms such as reducing inflammation, repairing intestinal barrier, releasing antimicrobial peptides (cAMPs), regulating iron overload, and inhibiting lipid peroxidation (182, 183), thereby ameliorating the pathological phenotype of IBD ( Figure 3 )
3 Coupled with the metabolic benefits of this drug, the Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT) trial showed a 20% reduction in major cardiovascular events with Semaglutide, making it the only weight loss medication to do so
Effect of D-Ala2GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice
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