TGF- has an inhibitory effect on Nrf2, which increases oxidative stress through the suppression of endogenous antioxidants [59]
Genes mentioned in the Article are indicated in bold
While the functional relevance of suboptimal riboflavin status in otherwise healthy individuals is not clear, in vitro studies have shown increased protein carbonylation, DNA strand breaks, and cellular stress and apoptosis with riboflavin deficiency associated with little to no glutathione reductase activity (211, 340)
5-methyl-THF, which may be used as an alternative to folic acid for food fortification and dietary supplementation, is produced synthetically from folic acid 1,353,625,626,627
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